TY - JOUR AU - Ghimire, Pukar AU - Pokharel, Anuradha AU - Aryal, Prakash AU - Bhandari, Rajan AU - Bhandari, Bibek PY - 2021/12/15 Y2 - 2024/03/29 TI - Clinical Profile of COVID-19 Patients Admitted in a COVID Designated Hospital JF - Journal of Nepal Health Research Council JA - J Nepal Health Res Counc VL - 19 IS - 03 SE - Original Article DO - 10.33314/jnhrc.v19i3.3649 UR - http://jnhrc.com.np/index.php/jnhrc/article/view/3649 SP - 587-595 AB - Background: Pandemic of COVID-19 has engulfed Nepal as well. In this paper, we studied the demographic, clinical, laboratory findings as well as the treatment modalities, prognostic factors and outcome of patients admitted with COVID-19.Methods: This was an observational cross-sectional study that included all patients admitted to the General Medicine Department of College of Medical Sciences, Bharatpur, during the first wave of COVID-19 from April 2020 to February 2021 after obtaining the ethical clearance. Data analysis was done using statistical packages for social sciences version 16.Results: A total of 119 patients with mean age of 61.5 years were admitted. They had a mean duration of onset of symptoms of 7.1 days. Commonest symptoms were fever (70.6%), cough (67.2%) and dyspnea (64.7%). Severe COVID-19 at admission with a median CT severity score of 15 was found in 49.7% of them. Total 83.2% patients required ICU care and 10.9% required mechanical ventilation. ARDS and secondary infection occurred in 17.6% each. Median length of hospital stay was 6 days. In total, 56.3% recovered 27.7% left against medical advice and 16.0% expired. Severity of COVID at admission, CT severity score at presentation and D-dimer at admission were found to be significantly associated with mortality (P<0.05).Neither of the age, duration of illness, CRP at admission nor the use of remdesivir or convalescent plasma had significant relation with the mortality (P>0.05).Conclusions: Severity of illness at presentation, CT severity score and D-dimer level at admission are significantly associated with mortality of the patients admitted with COVID-19.Keywords: COVID-19; prognosis; SARS-CoV-2 ER -