C-reactive Protein Versus Neutrophil/lymphocyte Ratio in Differentiating Bacterial and Non-bacterial Pneumonia in Children

  • Eva Gauchan Department of Pediatrics, Manipal Teaching Hospital, Pokhara, Nepal.
  • Sudhir Adhikari Department of Pediatrics, Manipal Teaching Hospital, Pokhara, Nepal.

Abstract

Background: Pneumonia is a leading cause of childhood mortality in a low resource country. Simple laboratory markers can help differentiate between bacterial and non-bacterial pneumonias for appropriate management.
Methods: In children aged one to 60 months with features of lower respiratory infection, C-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR) were used to differentiate between bacterial and non-bacterial pneumonias. The cutoff values for detecting bacterial pneumonias were evaluated by statistical tools.
Results: Bacterial pneumonia was diagnosed in 285 (43.6%) children out of 654 studied. At a cut-off value of 36 mg/L CRP was predictive of bacterial pneumonias with sensitivity and specificity of 61.8% and 91.3% respectively while the sensitivity and specificity for predicting bacterial pneumonia using NLR was 45.6% and 64% respectively with 1.28 used as a cut-off.
Conclusions: Our study shows that CRP is superior to NLR in differentiating bacterial from non-bacterial pneumonias in children.
Keywords: Bacterial and non-bacterial pneumonia; C-reactive protein; neutrophil to lymphocyte ratio.

Published
2017-03-14
How to Cite
GAUCHAN, Eva; ADHIKARI, Sudhir. C-reactive Protein Versus Neutrophil/lymphocyte Ratio in Differentiating Bacterial and Non-bacterial Pneumonia in Children. Journal of Nepal Health Research Council, [S.l.], mar. 2017. ISSN 1999-6217. Available at: <http://jnhrc.com.np/index.php/jnhrc/article/view/882>. Date accessed: 28 july 2017.
Section
Original Articles