Antibiotic Susceptibility Pattern of Bacteria Causing Urinary Tract Infection

  • Jatan Bahadur Sherchan Department of Microbiology, Kathmandu University School of Medical Sciences, Dhulikhel
  • Anjana Dongol Department of Obstetrics and Gynecology, Kathmandu University School of Medical Sciences, Dhulikhel
  • Sanjaya Humagain Department of Internal Medicine, Kathmandu University School of Medical Sciences, Dhulikhel
  • Anish Joshi Department of Pediatrics, Kathmandu University School of Medical Sciences, Dhulikhel
  • Siddha Rana Magar Department of Microbiology, Kathmandu University School of Medical Sciences, Dhulikhel
  • Sarita Bhandari Department of Microbiology, Kathmandu University School of Medical Sciences, Dhulikhel
DOI: https://doi.org/10.33314/jnhrc.v20i01.4142

Abstract

Background: Urinary tract infection is one of the commonest infectious diseases worldwide. This study was carried out to determine the antimicrobial susceptibility pattern of bacteria causing urinary tract infection visiting Kathmandu University Hospital.
Methods: A total of 3,500 urine samples were processed and antibiotic resistance pattern was determined following Clinical Laboratory Standard Institute guidelines. Patients’ information was obtained after informed consent.
Results: Total number of samples with positive growth was 434 (12.40%). 331 (76.27%) of the isolates were Escherichia coli followed by Klebsiella pneumoniae, Enterococcus spp., Pseudomonas aeruginosa, Staphylococcus saprophyticus, Proteus mirabilis, Enterobacter species, Klebsiella oxytoca, Citrobacter freundii, Proteus vulgaris, Staphylococcus aureus and Acinetobacter species. Over all 224 (51.61%) were multidrug resistant strains. All strains were sensitive to colistin, vancomycin and linezolid. Over all ampicillin and cefazolin had least sensitivity. Multidrug resistant strains were detected more among elderly patients with complicated urinary tract infection and diabetes which was 25 (83.33%) compared to elderly patients with uncomplicated urinary tract infection and having no diabetes or any other comorbid illnesses which was only 11(22.22%) (p-value<0.05). 21 (70.00%) of the pregnant females had multidrug resistant isolates and only 18 (36.73%) of pediatric age group patients had multidrug resistant isolates (p-value<0.05)
Conclusion: Drug-resistant bacteria were observed in urine samples. Effective treatment and prevention of urinary tract infection need detailed microbiological diagnosis and drug susceptibility testing.
Keywords: ESBL; MDR; UTI

Published
2022-06-02
How to Cite
SherchanJ. B., DongolA., HumagainS., JoshiA., Rana MagarS., & BhandariS. (2022). Antibiotic Susceptibility Pattern of Bacteria Causing Urinary Tract Infection. Journal of Nepal Health Research Council, 20(01), 218-224. https://doi.org/10.33314/jnhrc.v20i01.4142
Issue
Vol. 20 No. 01 (2022): Issue 54 Jan-March, 2022
Section
Original Article

Copyright (c) 2022 Jatan Bahadur Sherchan, Anjana Dongol, Sanjaya Humagain, Anish Joshi, Siddha Rana Magar, Sarita Bhandari

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