Distribution of Hemoglobinopathy in Nepalese Population

  • Rekha Manandhar Shrestha National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Roshan Pandit National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Udaya Kumar Yadav National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Rameshwar Das National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Binod Kumar Yadav Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal
  • Harish Chandra Upreti National Public Health Laboratory, Teku, Kathmandu, Nepal

Abstract

Background: Sickle cell and thalassemia are the inherited disorders of globin chain synthesis, and are the most common monogenic disease worldwide. This study aims to find the distribution of hemoglobinopathies (sickle cell and thalassemia) cases in Nepal using laboratory based data.
Methods: A retrospective study was carried out at five different sites of Nepal Government that uses capillary electrophoresis for screening of hemoglobin disorders from January 2019 to March 2019. All the cases diagnosed positive for hemoglobinopathy till December 2018 were collected from laboratory record at each sites, and analyzed using Statistical Package for Social Sciences (SPSS version 20.0).
Results: Out of total 4018 patients tested during the period in all five different sites, 1470 were diagnosed positive for hemoglobinopathy. Sickling disorder was the most predominant hemoglobinopathy followed by ?-thalassemia. Province 5, province 6 and province 7 were mostly affected by sickling disorder while the other provinces by ?-thalassemia.
Conclusions: Sickle cell is the commonest cause of hemoglobinopathy followed by B thallesmias in Nepalese population. Sickle cell is more concentrated towards western part of Nepal and especially in Tharu ethnic population. In contrast, the distribution of ?-thalassemia is found throughout the country and among all ethnic groups of population.
Keywords: Hemoglobinopathy; Nepal; sickle cell; thalassemia

Published
2020-04-20
How to Cite
SHRESTHA, Rekha Manandhar et al. Distribution of Hemoglobinopathy in Nepalese Population. Journal of Nepal Health Research Council, [S.l.], v. 18, n. 1, p. 52-58, apr. 2020. ISSN 1999-6217. Available at: <http://jnhrc.com.np/index.php/jnhrc/article/view/2303>. Date accessed: 25 may 2020. doi: https://doi.org/10.33314/jnhrc.v18i1.2303.